Vitamin B12 deficiency among vegetarian and non-vegetarian diabetic population receiving prolonged Metformin based oral hypoglycemic agents therapy

Vitamin B12 in Vegetarian Diets

Vitamin B12 (B12) belongs to a group of water soluble B-vitamins. Methylcobalamin and adenosylcobalamin are two biologically active forms of B12. Hydroxocobalamin, aquacobalamin, nitrocobalamin and cyanocobalamin are metabolized to either of the two active forms once ingested. B12 is essential in synthesis of methionine (methylcobalamin) and in metabolism of lipids, protein and carbohydrates (a...

Skin hyperpigmentation and increased angiogenesis secondary to vitamin B12 deficiency in a young vegetarian woman.

Metformin-related vitamin B12 deficiency.

Metformin is an invaluable hypoglycaemic agent. We report two cases who had symptomatic vitamin B12 deficiency related to metformin use; the mechanisms are discussed. The clinician must be aware of the possibility of metformin-associated B12 deficiency in users who suffer cognitive impairment, peripheral neuropathy, subacute combined degeneration of the cord or anaemia.

Association of Biochemical B12 Deficiency With Metformin Therapy and Vitamin B12 Supplements

OBJECTIVE To describe the prevalence of biochemical B(12) deficiency in adults with type 2 diabetes taking metformin compared with those not taking metformin and those without diabetes, and explore whether this relationship is modified by vitamin B(12) supplements. RESEARCH DESIGN AND METHODS Analysis of data on U.S. adults ≥50 years of age with (n = 1,621) or without type 2 diabetes (n = 6,8...

vitamin b۱۲ in vegetarian diets